NWO-subsidy for Sanne Abeln for research on the role of entropy in misfolding proteins

The NWO domain 'Sciences' has reserved 2 million Euros for research projects in fundamental Physics. One of the five awarded research projects has been proposed by Sanne Abeln of the Science faculty at the VU.

09/21/2017 | 7:53 AM

Delineating entropic contributions in beta-strand formation
In a healthy cell, proteins fold into compact structures with regions containing regular alpha helical and beta-strand configurations. In diseases such as Alzheimer’s, proteins misfold and bind to each other using this same beta-stranded structure. The underlying physics, particularly the configurational entropy that explains how favourable this beta-strand state is, is not properly understood. In this project we will tackle this problem by incorporating information extracted from unfolding experiments and from structural big data in large-scale computer simulations.

About NWO Physics
The Physics "Projectruimte" is an NWO subsidy that finances fundamental research in physics.

Read the article (in Dutch) on all proposals honored on the NWO website.