Posthuma will use ERC Grant for connecting genetics and neurobiology
Danielle Posthuma, professor of Complex Trait Genetics at VU Amsterdam and Amsterdam University Medical Center, location VUmc, and holder of a University Research Chair, received the prestigious European Research Council Advanced Grant this week. This is the largest personal research grant in Europe.
03/28/2019 | 2:46 PM
Revolution in genetics
The field of human genetics has seen some dramatic changes in the last decade. Posthuma: “The ongoing revolution in this field has taken us from merely being able to calculate what the relative contribution of genetic influences is for a trait, until specifically pinpointing the genes and genetic variants associated with traits. This jump also immediately revealed how "complex" certain disorders are, for example schizophrenia, depression, Alzheimer's disease and insomnia. These disorders are not influenced by a single gene, but sometimes by hundreds of genes. That complicates further research into how these genes influence the disease." Designing such follow-up studies that lead to mechanistic understanding of disorders, is one of the major goals of Posthuma’s ERC.
Revolution in neuroscience
Revolutionary developments have also taken place in the field of neuroscience over the past few years, says Posthuma. “For example, we can now look at expression patterns of thousands of genes at cellular level. When we link this knowledge to the new genetic discoveries, we can find out which specific cells play a role in these diseases. The functions of these cells in diseases etiology can then be investigated with recently developed techniques from neurobiology. This will yield mechanistic insight, yielding novel leads for treatment.”
The data sets with which Posthuma is going to work are very large and very diverse: for efficient processing and especially for linking multiple data sets, she wants to develop new methods that build a strong bridge between human genetics and neuroscience. The newly developed techniques will be applied to multiple brain-related disorders.