Tenure track position for Isabelle Kohler at the Division of Bioanalytical Chemistry

Dr. Isabelle Kohler has been appointed as tenure track researcher at the division of Bioanalytical Chemistry in the Department of Chemistry and Pharmaceutical Sciences. Her research focuses on the implementation of metabolomics-based approaches in clinical and forensic toxicology.

07/03/2020 | 5:13 PM

The main research interests of Isabelle Kohler lie at the intersection between bioanalysis, metabolomics, and toxicology. As an educated Pharmacist, she is interested in better understanding the pharmacokinetics and toxicokinetics of drugs and pharmaceutical compounds in the body. Her research expertise includes the development of state-of-the-art mass spectrometry-based approaches for the analysis of metabolites (i.e., small molecules such as drugs, drug metabolites, or endogenous compounds) in complex biological fluids and tissues.

During her tenure track at the VU (funded through the Dutch national “Sectorplan” scheme), she will develop novel analytical approaches based on metabolomics for clinical and forensic applications. She expects to build numerous and fruitful collaborations within the Amsterdam Institute of Molecular and Life Sciences to study drugs metabolism and toxicity using in vitro and in vivo metabolomics; she will also play a key role in the team operating the O|2 Metabolism Core Facility. Through collaborations with external partners such as Amsterdam UMC, the Netherlands Forensic Institute (NFI), the Rijksinstituut voor Volksgezondheid en milieu (RIVM), and Trimbos Institute among others, she expects to develop novel bioanalytical approaches with a high societal impact.

Isabelle Kohler obtained her MSc and Federal Diploma in Pharmacy at the University of Geneva in Switzerland. She received her PhD in 2013 at the School of Pharmaceutical Sciences (University of Geneva). Her PhD research focused on capillary electrophoresis – mass spectrometry and the development of high sensitive methods for clinical and forensic applications. The same year, she was awarded the Swiss Young Researcher Award in Analytical Chemistry from the Center of Expertise in Analytical Chemistry and Toxicology. She then obtained a grant from the Swiss National Science Foundation to continue her career abroad. She joined the Center for Proteomics and Metabolomics at the Leiden University Medical Center (LUMC) for a postdoc fellowship focused on the use of metabolomics (untargeted and targeted approaches) for investigating the biomolecular mechanisms of migraine at the metabolic level using a transgenic mouse model, a collaboration with the Department of Human Genetics at the LUMC.

Prior to joining the VU, she has been working for four years as an Assistant Professor at the Leiden Academic Center for Drug Research (LACDR) at Leiden University, in the group of Prof. Thomas Hankemeier, to further develop her expertise in clinical metabolomics, notably in the context of neurological disorders. Besides research and supervision of PhD students, Isabelle Kohler has been actively involved in teaching as well as education coordination and innovation for the BSc and MSc Biopharmaceutical Sciences. Her enthusiasm and teaching skills have been appreciated by the students, as highlighted by her nomination in 2018 to the Faculty of Sciences Teaching Award.