Division of Bio-Organic and Synthetic Chemistry

Romano Orru           Tom Grossmann           Eelco Ruijter - nw           Sven Hennig - nw

Prof. Dr. Ir. Romano Orru    Prof. Dr. Tom Grossmann     Dr. Eelco Ruijter                    Dr. Sven Hennig

The Division of Organic Chemistry consists of two chairs: 

  • Synthetic & Bio-organic Chemistry
  • Organic and Peptide Chemistry

Synthetic & Bio-organic Chemistry

The Synthetic & Bio-organic Chemistry research group of Prof. Romano Orru focuses on the development of highly efficient, asymmetric synthetic methodologies and their application to the synthesis of diverse, biologically relevant compounds, with an emphasis on atom and resource efficiency. 

Three main areas of interest can be distinguished:

  • Rational design and development of flexible novel cascade and multicomponent reactions (MCRs).
  • Use of biocatalysts for the production of enantiopure building blocks for asymmetric synthesis.
  • Development of asymmetric versions of MCRs and related processes using biocatalysis and/or homogeneous catalysis.

The group's efforts in this area have resulted in the development of several novel MCRs and other cascade reactions furnishing valuable heterocycles. Another goal is the integration of the group’s successes in MCR chemistry and biocatalysis in approaches towards the total synthesis of complex natural products.

The following subgroups are associated with this chair:

Dr. Eelco Ruijter: Molecular Diversity and Complexity

Group website: www.syborch.com

Organic and Peptide Chemistry

The Organic and Peptide Chemistry research group headed by Prof. Tom N. Grossmann focuses on the design of peptide-derived molecules (so called peptidomimetics) as modulators of therapeutically relevant biological targets. The research focuses on three main areas:

  • New methodologies for the stabilization of peptide secondary and tertiary structures
  • Understanding and increasing the cellular uptake of peptidomimetics
  • Structure-based design of inhibitors of protein-protein interactions

The group has an expertise in the synthesis of non-natural amino acids, solid phase synthesis of modified peptides and heterologous protein expression. In addition, the biophysical characterization of ligands with proteins and oligonucleotides is performed using X-ray crystallography, isothermal titration calorimetry and fluorescence polarization assays (among others).

The following subgroups are associated with this chair:

Dr. Sven Hennig: Structural Chemical Biology

Group website: www.grossmannlab.com