Stabilization of peptide secondary and tertiary structures

Selected publications:

DM Krüger, A Glas, D Bier, N Pospiech, K Wallraven, L Dietrich, C Ottmann, O Koch, S Hennig, TN Grossmann, Structure-based design of non-natural macrocyclic peptides that inhibit protein-protein interactions, J. Med. Chem., 60, 8982–8988 (2017)

L Dietrich, B Rathmer, K Ewan, T Bange, S Heinrichs, TC Dale, D Schade, TN Grossmann, Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein‒protein interactions, Cell Chem. Biol., 24, 958–968 (2017)

PM Cromm, S Schaubach, J Spiegel, A Fürstner, TN Grossmann, H Waldmann, Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides, Nature Commun., 7, 11300 (2016)

M Pelay‑Gimeno, A Glas, O Koch, TN Grossmann, Structure-based design of inhibitors of protein-protein interactions: Mimicking peptide binding epitopes, Angew. Chem. Int. Ed., 54, 8896–8927 (2015)