Open e-infrastructure to support data sharing, knowledge integration and in silico analysis and modelling in risk assessment

OpenRiskNet is a 3 year project funded under the Horizon 2020 EINFRA-22-2016 Programme. The main objective is to provide an open e-Infrastructure providing resources and services to a variety of communities requiring risk assessment, including chemicals, cosmetic ingredients, therapeutic agents and nanomaterials. OpenRiskNet will work with a network of partners, organized within an Associated Partners Programme.

Toxicology and risk assessment are undergoing a paradigm shift, from a phenomenological to a mechanistic discipline based on in vitro and in silico approaches that represent an important alternative to classical animal testing applied to the evaluation of chronic and systemic toxicity risks. Large databases and highly sophisticated methods, algorithms and tools are available for different tasks such as hazard prediction, toxicokinetics, and in vitro – in vivo extrapolations to support this transition.

However, since these services are developed independently and provided by different groups world-wide, there is no standardized way to access the data or run modelling workflows. To overcome the fragmentation of data and tools, OpenRiskNet will provide open e-Infrastructure resources and services supporting different scientific communities.

Website OpenRiskNet