Valorisation & Products


Amsterdam Piezo Valve
The Amsterdam Piezo Valve produces short (<20 microsec) and intense pulsed atomic and molecular beams. It can operate both in continuous and in pulsed mode (DC - 5 kHz). The short pulse duration makes the valve very suited for applications in combination with pulsed lasers. Because of the short pulse duration the Amsterdam Piezo Valve consumes typically a factor of ten less sample relative to a conventional pulsed plunger valve, saving a lot of sample that is otherwise wasted. The low gas load makes the design of the vacuum apparatus much simpler, requiring smaller pumps and saving financial resources. 

The Amsterdam Piezo Valve is developed by former Prof. Maurice Janssen, FMIB and Elektronica Beta. The Amsterdam Piezo Valve is produced by us and commercialized by our partner MassSpecpecD BV, the Netherlands. The Amsterdam Piezo Valve has been purchased by many (> 50) research groups and institutes, amongst them:

Fritz Haber Institute, Max Planck Gesellschaft Berlin, Germany
DESY, CFEL and XFEL, Hamburg, Germany
SwissFEL and the Paul Scherrer Institute, Villingen, Switzerland
Argonne National Laboratories, USA
Korea Advanced Institute of Science and Technology, Korea
Rutherford Appleton Laboratory, United Kingdom
Beijing University, China
CNRS Bordeaux, France
Sandia National Laboratories, Livermore, USA
University of Tokyo, Japan
East China Normal University, Shanghai, China
University of California, Santa Barbara, USA
ETH, Zurich, Switzerland
University of British Columbia, Vancouver, Canada
IBM (Thomas J. Watson Research Center), USA

Fast identification of water hazards


Of course you know that our planet contains more than 70% of water. It is the source of every form of life on earth. We can’t live without it.

All kinds of emerging contaminants, including pharmaceuticals, endocrine disrupting compounds and perfluorinated compounds, are present in the aquatic environment, wastewater and drinking water sources. In addition, numerous bioassay surveys have demonstrated the presence of not yet identified compounds with toxic activities in the environment, which is evidently of high concern. For example, genotoxic and endocrine disrupting compounds may lead to DNA damage, to disruption of development and reproduction and/or to cancer.

Therefore, the importance of paying attention to emissions and pollution is rising with each day. We have to ensure ourselves, for the sake of every living being, that the water we drink or use is 100% pure. Mistakes are inadmissible. To make sure of this, we introduce FractioMateTM.

FractioMateTM converts complex, costly and lengthy EDA studies into robust, rapid and sensitive analyses which also significantly increase toxic compound identification.

  • Direct integration of biological and chemical lab.
  • Lengthy EDA studies reduced to a few days.
  • Capacity increase by orders of magnitude; resulting in 5 to 10 samples per week.
  • Integration results in much faster correlation of bioactivity / toxicity to accurate mass.
  • foto Fractiomate\scheme.jpg

High Throughput Effect Directed Analysis - FractioMate based on the SPARK Integrity as linking technology for chemical and biological analysis.

Compounds in a sample are separated with liquid chromatography (LC). Subsequently, the eluent is split where one part is transferred by means of the innovative FractioMate spotting technology to a high-resolution bioassay (e.g. 96 or 384 well mammalian or yeast-based cellular format) to test the biological activity of eluting compounds. The other part is directed to a mass spectrometer. Peak shapes from ‘reconstructed bioassay chromatograms’ using the individually collected and bioassayed fractions are efficiently correlated to compound accurate masses from the parallel obtained chemical data (in most cases MS data).

In the BioMolecular Analysis group and the department of Environment & Health of the Faculty of Science, excellent research and training to better understand the impact of environmental contaminants on human health and the environment is carried out. For HT-EDA research the FractioMateTM was developed in close collaboration with the VU Engineering Groups on Electronics and Precision Mechanics. Under the name Tec4Science this development is made available for other research groups outside the VU.

Download the FractioMate flyer here.